HIE causes neuronal and white matter injury of the brain, which results in diverse life-long neurological sequelae such as cerebral palsy.
Although hypothermia is applied to HIE, it has little therapeutic effect. In addition, in many cases, hypothermia cannot be applied to patients.
HIEstem is a second-generation cell therapeutics whose therapeutic effects are potentiated by Thrombin pre-conditioning (patent-technology of Medinno inc.)
HIEstem treats HIE by neuro-protection, anti-inflammatory effects, and anti-gliosis effects. Project code of HIEstem for HIE is MS1901.
from Wharton’s Jelly of Umbilical Cord
Wharton’s Jelly-derived Mesenchymal Stem Cells
Enhancing Therapeutic Effects of Wharton's Jelly-derived Mesenchymal Stem Cells
Thrombin pre-conditioned Wharton’s Jelly-derived Mesenchymal Stem Cells (HIEstem)