HIEstem for HIE | 메디노

HIEstem HIEstem is a second-generation cell therapeutics whose therapeutic effects are potentiated by Thrombin pre-conditioning (patent-technology of Medinno inc.) HIEstem treats HIE by neuro-protection, anti-inflammatory effects, and anti-gliosis effects. Project code of HIEstem for HIE is MS1901.

PIPELINE

01. Primary Culture of Mesenchymal Stem Cells

from Wharton’s Jelly of Umbilical Cord

02. Drug Substrate (DS)

Wharton’s Jelly-derived Mesenchymal Stem Cells

03. Thrombin Pre-conditioning

Enhancing Therapeutic Effects of Wharton's Jelly-derived Mesenchymal Stem Cells

04. Drug Product (DP)

Thrombin pre-conditioned Wharton’s Jelly-derived Mesenchymal Stem Cells (HIEstem)

Non-clinical Data

In vivo Neuro-Protective Effect HIEstem reduced brain injury area (white in MRI) in HIE animal models
- HNC = No treatment,
- HHC = Hypothermia,
- HHM = Hypothermia + Wharton’s Jelly-derived Mesenchymal Stem Cells,
- HHT = Hypothermia + HIEstem (Thrombin pre-conditioned Wharton’s Jelly-derived Mesenchymal Stem Cells)
In vivo Immuno-Suppressive Effect Inflammatory cytokines in brains were reduced by HIEstem
- NNC = Normal control,
- HNC = No treatment, HHC = Hypothermia,
- HHM = Hypothermia + Wharton’s Jelly-derived Mesenchymal Stem Cells,
- HHT = Hypothermia + HIEstem (Thrombin pre-conditioned Wharton’s Jelly-derived Mesenchymal Stem Cells) In vitro Neuro-Protective Effect HIEstem reduced neuronal death in vitro
- OGD = Oxygen-Glucose Deprivation
- Naive MSC = Wharton’s Jelly-derived Mesenchymal Stem Cells,
- Thrombin MSC = HIEstem (Thrombin pre-conditioned Wharton’s Jelly-derived Mesenchymal Stem Cells)