ahNSC for Stroke | 메디노

Stroke induces diverse permanent neuromuscular sequalae including hemiplegia.
Early thrombolytic intervention is the only proven therapeutic option for stroke, which is hard to be applied to most stroke patients.

Adult Human Neural Stem Cell ahNSCs are derived from adult human brain and make therapeutic effects for stroke by differentiation into neural cells and secretion of neuroprotective, anti-gliosis, pro-angiogenic, and anti-inflammatory paracrine factors. Project code of ahNSCs for Stroke is MS2101.

PIPELINE

01. Isolation of Brain Clumps

from Adult Human Temporal Lobe

02. Adult Human Neural Stem Cells (ahNSCs)

Primary Culture of Brain Clumps

03. Drug Product (DP)

Adult Human Neural Stem Cells (ahNSCs)

Non-clinical Data

In vivo therapeutic effect of adult human Neural Stem Cells Brain tissue loss was reduced by transplantation of adult human Neural Stem Cells into the animal models of stroke. In vivo Functional Recovery Motor functions were improved in Rota rod test by adult human Neural Stem Cell treatment In vivo & In vitro neuro-protective effects More neural cells survived in the ischemic sites by adult human Neural Stem Cell treatment. In vivo Functional Recovery Cognitive functions were improved in passive avoidance test by adult human Neural Stem Cell treatment

Development Stage

IND
Phase1
Phase2
BLA

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